Mononeuritis multiplex is a rare autoimmune peripheral neuropathy that typically presents in the context of vasculitis, diabetes, infection, or as a paraneoplastic syndrome. Adverse immune-related neurological conditions have been increasingly reported with the use of immune checkpoint inhibitors against cytotoxic T-lymphocyte antigen-4 and/or the programmed cell death protein 1/programmed death ligand-1 axis. Mononeuritis multiplex has only been reported twice from treatment of cancers with immunotherapy. Clinical case study report :  Learn more

 The human brian is made up of more than 100 billion nerve cells called neurons. Each neuron is connected to as many as 25000 other neurons-so the brain has trillions and trillions of different pathways for nerve signals. Girls' brains weight 2.5% of their body weight, on average, while boy's brains weigh 2%. About 0.85 litres of blood shorts through your brain every minute. The brain may be as little as 2% of your body weight, but it demand 25% of your blood supply. An elephant's brain weighs four times as much as the human brain. However, our brains are far bigger in relation to our bodies than those of any other animal. The cerebral cortex is the outside of the brain, and if it was laid out flat, it would cover a bed. The left hemisphere (half) of the brain is usually the word side, where the speech centres are. The right half is the picture side. Conscious thoughts and actions happen in the cerebral cortex. A human brain has a cerebral cortex four times as big as a chim

  Scientists can run invasive studies of the human brain only in special cases. Medical devices implanted to assess or treat certain conditions offer the chance to gather additional data for research. Listening in on neurons at close range can yield basic insights into brain function. Awake surgeries to insert such devices or resect tumors can sometimes be paused briefly for an unrelated experiment. Fried estimates roughly 30 groups in North America now do intracranial human neuroscience in epilepsy surgery patients—up from fewer than 10 when he started in the field, about 20 years ago. Researchers can also tap into therapeutic devices that stay in the brain long-term, some of which both deliver electrical stimulation and read out neural activity. Such implants are still underused sources of neural data, says UC Los Angeles (UCLA) neuroscientist Nanthia Suthana, who has used their recordings to study learning, memory, and spatial navigation. Another rare opportunity comes from people w

  A US man has become the first person in the world to get a heart transplant from a genetically-modified pig. David Bennett, 57, is doing well three days after the experimental seven-hour procedure in Baltimore, doctors say. The transplant was considered the last hope of saving Mr Bennett's life, though it is not yet clear what his long-term chances of survival are. "It was either die or do this transplant," Mr Bennett explained a day before the surgery. "I know it's a shot in the dark, but it's my last choice," he said. Doctors at the University of Maryland Medical Center were granted a special dispensation by the US medical regulator to carry out the procedure, on the basis that Mr Bennett - who has terminal heart disease - would otherwise have died. He had been deemed ineligible for a human transplant, a decision that is often taken by doctors when the patient is in very poor health. The pig used in the transplant had been genetically modified to kno

  NIH scientists urge pursuit of universal coronavirus vaccine Transmission electron micrograph of SARS-CoV-2 virus particles (gold) within endosomes of a heavily infected nasal Olfactory Epithelial Cell. NIAID A growing body of scientific evidence, considered together with ecological reality, strongly suggest that novel coronaviruses will continue to infect bats and other animal reservoirs and potentially emerge to pose a pandemic threat to humans. To counter future coronavirus outbreaks, the global scientific and medical research community should focus a major effort now on three goals: characterize the range of coronavirus genetic diversity in multiple animal species; better understand coronavirus disease pathogenesis in laboratory animal models and people; and apply this knowledge to the development of long-lasting, broadly protective coronavirus vaccines. So argue physician-scientists Anthony S. Fauci, M.D., Jeffery K. Taubenberger, M.D., Ph.D., and David M. Morens, M.D., of the N

  10 Natural Ways to Lower Your Cholesterol Levels Cholesterol is made in your liver and has many important functions. For example, it helps keep the walls of your cells flexible and is needed to make several hormones. However, like anything in the body, too much cholesterol (or cholesterol in the wrong places) creates concerns. Like fat, cholesterol does not dissolve in water. Instead, to move around the body, it depends on molecules called lipoproteins. These carry cholesterol, fat, and fat-soluble vitamins in your blood. Different kinds of lipoproteins have different effects on health. For example, high levels of low-density lipoprotein (LDL) results in cholesterol deposits in blood vessel walls, which can lead to  Trusted Sou clogged arteries stroke heart attack kidney failure In contrast, high-density lipoprotein (HDL) helps carry cholesterol away from vessel walls and helps prevent these conditions ( 2 Trusted Source ). There are many natural ways to increase HDL (good) cholester