Health Ask the Expert: What Do I Need to Know About How Multiple Sclerosis Affects the Brain? Written by Barbara S. Giesser, MD 1. Multiple sclerosis (MS) is a condition of the central nervous system, which includes the brain, spinal cord, and optic nerve. How does MS affect these areas, and what are some of the issues MS causes with brain health specifically? Nerves communicate with each other and with the rest of the body by sending electrical and chemical signals. To understand how your nerves work, think about how they’re similar to electrical cables. Nerves consist of a “wire,” which we call the axon. The axon is covered by insulating material called myelin. MS damages the myelin so that the nerve’s ability to conduct electrical signals is slowed and uncoordinated. If the axon is also damaged, the electrical signal may be blocked entirely. When this happens, the nerve can’t send appropriate information. This produces symptoms. For example, if a muscle doesn’t receive s