neurological diseases

Oxidative stress is a key a therapeutic target for many neurological diseases.

A strong rationale for oxidative stress in a given neurological disease should be the guiding factor for antioxidant therapy.

Antioxidant drug development should account for both the beneficial and the harmful effects of reactive oxygen species.

Biomarkers to monitor target engagement can guide antioxidant clinical trials for neurological diseases.

There is widespread recognition that reactive oxygen species (ROS) play key roles in normal brain function and pathology in the context of neurological disease. Oxidative stress continues to be a key therapeutic target for neurological diseases. In developing antioxidant therapies for neurological disease, special attention should be given to the brain's unique vulnerability to oxidative insults and its architecture. Consideration of antioxidant therapy should be guided by a strong rationale for oxidative stress in a given neurological disease. This review provides an overview of processes that can guide the development of antioxidant therapies in neurological diseases, such as knowledge of basic redox mechanisms, unique features of brain pathophysiology, mechanisms and classes of antioxidants, and desirable properties of drug candidates.

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World’s ‘best’ vaccines could soon come to poor countries

Health World’s ‘best’ vaccines could soon come to poor countries -By Vishnu /11/5/21 In the 6 months since Covid vaccines became available, those based on mRNA technology have scored top marks. So far, there are only two – made by Pfizer and Moderna – and both show 95% efficacy. Other types of vaccines are usually 80% or less efficacious. This difference affects not only the protection you get as an individual but also the protection available to the ‘herd’ or society. With a better vaccine a country can reach ‘herd immunity’ faster by vaccinating fewer people. But mRNA vaccines are still confined to the rich world. This is partly because supply is limited and those countries placed their orders first. Another reason is these vaccines get spoilt if they are not stored at extremely cold temperatures. The Pfizer shot initially required storage at -80°C. Poor countries couldn’t afford to buy specialised freezers for it in bulk. A fragile molecule Why do mRNA vaccines need ultra-cold stora

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Health info / news/

Vexplorehealth Health Information News Helpful Tips for Managing Chronic Kidney Disease Chronic kidney disease (CKD) is a serious condition affecting 37 million U.S. adults and is often overlooked until symptoms appear. As we continue to observe National Kidney Month this March, learn how adopting a healthy lifestyle can help manage and slow the progression of CKD and its complications. Watch this video for tips to help people with CKD take charge of their kidney health.

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